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NCT05133505 Clinical Trial

Characterisation of TIM-3/Gal-9 Immune Checkpoints in Primary Central Nervous System Diffuse Large B Cell Lymphomas

Lymphoma, B-Cell Clinical Trial

Official title:
Characterisation of TIM-3/Gal-9 Immune Checkpoints in Primary Central Nervous System Diffuse Large B Cell Lymphomas

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05133505
Other study ID # RECHMPL21_0665
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2002
Est. completion date November 1, 2021

Study information
Verified date November 2021
Source University Hospital, Montpellier
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Primary central nervous system diffuse large B cell lymphoma is a rare and aggressive entity of diffuse large B cell lymphoma. A previous transcriptomic study showed an overexpression of TIM-3 and Gal-9 in the tumor microenvironment. The investigators aimed to characterise TIM-3/Gal-9 immune checkpoints by using immunohistochemistry in the tumor microenvironment of primary central nervous system diffuse large B cell lymphoma.

Recruitment information / eligibility
Status Completed
Enrollment 65
Est. completion date November 1, 2021
Est. primary completion date October 1, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion criteria: - patient with a Diagnosis of LBDGC-SNC Exclusion criteria: - immunocompromised patients - patients with a history of previous or associated low-grade lymphoma - patients with a history of systemic LBDGC with secondary localization to the SNC

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
France Uh Montpellier Montpellier

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary TIM-3 and Gal-9 immunohistochemical expression TIM-3 and Gal-9 immunohistochemical expression by tumor and microenvironment cells 1 day
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