The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

Lung Transplant Recipients Clinical Trial

Official title:

A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00284726
• Other study ID #: 00-10-25-03
• Status: Completed
• Phase: Phase 3
• Start date: December 2000
• Est. completion date: September 2005

Study information

• Verified date: December 2017
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Description:

The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: September 2005
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Ischemia
• Lung Transplant Recipients

Intervention

Device:
• Celsior Cold Storage Solution

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Johns Hopkins University