A Study Comparing Hypofractionated Dose Escalated VMAT to Conventional CCRT in Locally Advanced Head and Neck Cancer

Locally Advanced Head and Neck Cancer Clinical Trial

Official title:
A Clinical Study Comparing Hypofractionated Dose Escalated VMAT to Conventional CCRT in Locally Advanced Head and Neck Cancer

Status Active, not recruiting

Clinical Trial Summary

To compare efficacy and toxicity between hypofractionated dose escalated VMAT versus conventional concurrent chemoradiation in locally advanced head and neck cancer

Clinical Trial Description

patients were randomized to receive either: 70Gy in 35fx in 7wks at 2Gy/fx concurrently with weekly cisplatin 40mg/m2 (Arm A) or 74Gy in 33 fractions (fx) in 6.5 weeks at 2.24Gy/fx (Arm B). Volumetric Modulated Arc Therapy (VMAT) plans were created for both treatment arms ;

Study Design

Related Conditions & MeSH terms

Head and Neck Neoplasms
Locally Advanced Head and Neck Cancer

Clinical Trial Details

NCT number	NCT03699969
Study type	Interventional
Source	Cairo University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	January 1, 2016
Completion date	October 15, 2018

View Details

See also
Status	Clinical Trial	Phase
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Completed	`NCT01969877` - A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.	Phase 3
Completed	`NCT03317730` - Pilot Trial of Microsphere Oxycodone (Xtampza ER) for Pain Management in Patients Receiving Radiotherapy for Locally Advanced Head and Neck Cancer	Early Phase 1
Recruiting	`NCT01212354` - Impact of Selective Radiation Dose Escalation and Tumour Hypoxia Status on Locoregional Tumour Control After Radiochemotherapy of HNT	Phase 3
Recruiting	`NCT02976051` - DAHANCA 33: Image Guided Dose-escalated Radiotherapy to Patients With Hypoxic HNSCC	Phase 2