Liver Diseases Clinical Trial
Official title:
Prothrombin Complex Concentrate and Fresh Frozen Plasma in Viscoelastic Test-based Goal-directed Bleeding Management in Liver Transplantation Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for liver transplantation surgery.
| Status | Not yet recruiting |
| Enrollment | 92 |
| Est. completion date | April 1, 2025 |
| Est. primary completion date | April 1, 2025 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 20 Years to 75 Years |
| Eligibility | Inclusion Criteria: - Liver disease undergoing Liver transplantation Exclusion Criteria: - |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Konkuk University Medical Center |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | duration from the time diagnosing r-time prolongation to the time achieving bleeding control | 1 min | ||
| Secondary | Red Blood Cell amount | Red Blood Cell transfusion amount during surgery | 1 hour | |
| Secondary | FFP amount | FFP transfusion amount during surgery | 1 hour | |
| Secondary | Platelet amount | Platelet transfusion amount during surgery | 1 hour | |
| Secondary | r-time | CK r-time after PCC or FFP | 10 min | |
| Secondary | CRT-MA | CRT-MA after PCC or FFP | 10 min | |
| Secondary | CFF-MA | CFF-MA after PCC or FFP | 10 min | |
| Secondary | Bleeding | Postoperative bleeding amount | 6 hour | |
| Secondary | oxygenation profile | PaO2/FiO2 ratio | 1 hour |
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