Lichen Penis Planus Clinical Trial
Official title:
Clinical Evaluation of Glutamine Combined With Topical Corticosteroids in the Treatment of Erosive Oral Lichen Planus
Lichen planus (LP) is an inflammatory skin disease of unknown etiology. Glutamine promotes protein and collagen synthesis, imparts immunity, and maintains the alimentary canal mucosa structure.
Lichen planus (LP) is an inflammatory skin disease of unknown etiology. Recently, increased
oxidative stress has been implicated in the pathogenesis of erosive oral lichen planus
(EOLP). Glutamine is a source of energy for fibroblasts, immunocompetent cells, and
intestinal epithelial cells involved in collagen production. It promotes protein and collagen
synthesis, imparts immunity, and maintains the alimentary canal mucosa structure.
The aim of this study is to evaluate the effect of Glutamine combined with topical
corticosteroid in the treatment of oral erosive LP.
Thirty patients with a confirmed clinical and histopathologic diagnosis of OLP recruited in
this study and divided into 2 equal groups, each consisting of 15 subjects. Group 1 consists
of patients treated with topical steroids plus antifungal (conventional therapy); Group 2
consists of patients treated with Glutamine combined with topical steroids plus antifungal.
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