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Clinical Trial Summary

Patients with relapsed or refractory leukemia or lymphoma are often refractory to further chemotherapy. In this study, the investigators will attempt to use T cells obtained directly from the patient, which can be genetically engineered to express a chimeric antigen receptor (CAR). The CAR used in this study can recognize CD22, a protein expressed on the surface of leukemia and lymphoma cells. The phase 1 part of this study will determine the safety and appropriate dose level of these CAR T cells, and the phase 2 part of the study will determine how effective this CAR T cell therapy is. Both patients who have never had prior CAR T cell therapy and those who have had prior CAR T cell therapy may be eligible to participate in this study.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04571138
Study type Interventional
Source Seattle Children's Hospital
Contact Corinne Summers, MD
Phone 206-987-2106
Email CBDCIntake@seattlechildrens.org
Status Recruiting
Phase Phase 1/Phase 2
Start date September 25, 2020
Completion date February 2039

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