Protection Against Benzene Toxicity

Leukemia Clinical Trial

Official title:

NQO1 in Protection Against Benzene Toxicity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00011453
• Other study ID #: 9554-CP-001
• Status: Completed
• Phase: N/A
• First received: February 21, 2001
• Last updated: June 23, 2005
• Start date: July 1998
• Est. completion date: June 2001

Study information

• Verified date: July 2002
• Source: National Institute of Environmental Health Sciences (NIEHS)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: June 2001
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 65 Years

Eligibility

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

Study Design

Primary Purpose: Screening, Time Perspective: Prospective

Related Conditions & MeSH terms

• Anemia, Aplastic
• Aplastic Anemia
• Leukemia

Locations

Country	Name	City	State
United States	University of Colorado Health Sciences Center	Denver	Colorado

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Country where clinical trial is conducted

United States,