Leukemia Clinical Trial
Official title:
PHASE II STUDY EVALUATING AUTOLOGOUS PERIPHERAL BLOOD PROGENITOR CELL TRANSPLANTATION FOR ACUTE LEUKEMIAS
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Combining chemotherapy with peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill
more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of high-dose radiation therapy and
etoposide followed by peripheral stem cell transplantation in treating patients with acute
leukemia.
OBJECTIVES: I. Evaluate the efficacy of myeloablative total-body irradiation and etoposide
followed by autologous peripheral blood stem cell (PBSC) transplantation in prolonging the
disease-free survival of patients with acute leukemia. II. Investigate the ability of growth
factor-primed PBSC to provide hematopoietic reconstitution following myeloablative therapy.
OUTLINE: Patients are treated on Regimen A, then Regimen B. Regimen A: Stem Cell
Mobilization. Granulocyte Colony Stimulating Factor (Amgen), G-CSF, NSC-614629. Regimen B:
Radiotherapy and Myeloablative Chemotherapy with Hematopoietic Rescue. Total-Body
Irradiation, TBI (high-energy electrons used for lung boost); and Etoposide, VP-16,
NSC-141540; with Peripheral Blood Stem Cells, PBSC; G-CSF.
PROJECTED ACCRUAL: Up to 45 patients will be studied over approximately 3 years.
;
Primary Purpose: Treatment
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