Kidney Disease, Chronic Clinical Trial
Official title:
Drug-gene-nutraceutical Interactions of Cannabidiol and Tacrolimus
The information learned in these studies will help to inform doctors as to how to appropriately adjust doses of cannabidiol and tacrolimus in order to improve health outcomes and long-term treatment success for transplant recipients.
The commercial availability of cannabidiol, or CBD oil, has increased in the United Stated and this supplement has the potential to cause a variety of drug-drug interactions, including in solid organ transplant recipients who receive tacrolimus to prevent rejection. Through a series of pharmacokinetic and pharmacodynamics assays, this proposal will identify gene-drug and drug-drug interactions (DDI), including those that place transplant recipients at risk for increased toxicity related to their immunosuppression. The information learned in these studies will help to inform practitioners as to whether cannabidiol needs to be avoided in transplant recipients and how to appropriately adjust doses of CBD and immunosuppression in order to improve health outcomes and long-term treatment success in this high-risk population. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03907657 -
Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau
|
Phase 2 | |
| Completed |
NCT02468401 -
Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions
|
N/A | |
| Completed |
NCT02238067 -
Survey on Anemia Therapy in Patients With Chronic Kidney Disease Not on Dialysis
|
N/A | |
| Completed |
NCT01194154 -
A Study of Methoxy Polyethylene Glycol-epoetin Beta (Mircera) in Participants With Chronic Kidney Disease (PRIMAVERA)
|
Phase 2 | |
| Completed |
NCT02263833 -
An Observational, Prospective, Safety Study of Mircera (Monopegylated Epoetin Beta) in Clinical Practice
|
N/A | |
| Recruiting |
NCT04078750 -
PLATO - Medication Adherence in Transplant Recipients
|
N/A | |
| Terminated |
NCT05747053 -
Personalization of Immunosuppressive Treatment for Organ Transplant Recipients
|
||
| Completed |
NCT03189212 -
Feasibility Study of Telemedicine for Dialysis Patients Awaiting Transplantation
|
N/A | |
| Enrolling by invitation |
NCT05374291 -
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
|
Phase 3 | |
| Recruiting |
NCT05033054 -
Effect of SGLT2i on Cardiovascular Biomarkers in Patients With Type 2 Diabetes and CKD Stage 3b-4
|
||
| Completed |
NCT05064267 -
Hemostatic Profiles in Pediatric CKD
|
||
| Not yet recruiting |
NCT06069518 -
Continuous Glucose Monitoring in Patients With Diabetes on Peritoneal Dialysis
|
||
| Not yet recruiting |
NCT03590067 -
Oral Findings in a Group of Egyptian Pediatric Patients at Endstage Renal Disease
|
||
| Recruiting |
NCT04014127 -
Coronary Microvascular Dysfunction in Chronic Kidney Disease
|
||
| Recruiting |
NCT04626323 -
Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease
|
Phase 2 | |
| Not yet recruiting |
NCT05774392 -
An Observational Study of Patients With Chronic Kidney Disease
|
||
| Recruiting |
NCT03615235 -
APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
|
||
| Not yet recruiting |
NCT06343727 -
A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF)
|
N/A | |
| Completed |
NCT04515797 -
QUICKly Eradicate Hepatitis C in Patients Undergoing REnal Transplant With 4 Weeks of Glecaprevir/Pibrentasvir
|
Phase 4 | |
| Completed |
NCT03850756 -
Early Diagnosis of Kidney Damage Associated With Tobacco Use
|