Keratoconjunctivitis Sicca Clinical Trial
Official title:
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the
preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells
in order to determine if there are certain characteristics which might predict those
patients who will experience serious dry eye symptoms and complications after refractive
surgery.
Research Design: This study is a twelve-month prospective non-randomized investigation.
Methodology: In conjunction with psychometric questionnaires and various measures of tear
film quality (e.g. Schirmer's test, tear break up time, etc), impression cytology will be
used to assess the intracellular signaling pathways of conjunctival goblet cells and to
determine if alterations in this pathway exist. Alterations in this pathway would result in
a reduced response by the mucin secreting conjunctival goblet cells thereby promoting the
development of dry eye after refractive surgery.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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