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Clinical Trial Summary

The purpose of this study is to learn more about how adult and children's bodies use etanercept and how bodyweight influences how well etanercept works. This study will help us understand the proper dose of etanercept in obese children and adults.


Clinical Trial Description

PRECISE is an open-label, single arm, single-center site study to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of dosing interval-optimized etanercept in obese patients with Rheumatoid Arthritis (RA) and Juvenile Idiopathic Arthritis (JIA). Approximately 30 patients with JIA or RA who are starting etanercept standard-of-care will take part in the study. Eligible patients will have blood collections before and after starting the biologic of interest to assess PK and disease activity. Five (5) blood samples will be collected through a combination of clinic and home visits. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04585711
Study type Interventional
Source Duke University
Contact Balevic Stephen, MD
Phone 919-668-4544
Email Stephen.balevic@duke.edu
Status Not yet recruiting
Phase Phase 1
Start date July 1, 2024
Completion date February 28, 2025

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