Juvenile Idiopathic Arthritis Clinical Trial
Official title:
Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα
During exercise, energy comes mainly from carbohydrates and lipids. The relative
contribution of lipids and glucose as energy substrates to exercise depends on the
parameters of the exercise (duration, intensity and level of training) and the physiological
conditions of the subject.
Inflammatory diseases such as juvenile idiopathic arthritis (JIA) are treated, for the most
severe forms, by biotherapies. These treatments target certain pro-inflammatory cytokines
including TNFα. In adults with rheumatoid arthritis several studies have shown that
treatment with anti-TNFα increases insulin sensitivity. There is no data on the oxidation of
energy substrates during exercise in children and adolescents with AJI, nor on the impact of
anti-TNFα treatments on the oxidation of energetic substrates in children.
Investigators hypothesize that, compared to healthy children, children with JIA should
exhibit altered oxidation of energy substrates at rest and submaximal physical exercise due
to physical deconditioning and inflammation. In addition, those treated with anti-TNFα
should have an oxidation profile of energy substrates at exercise different from that of
patients not treated with anti-TNFα. Investigators also hypothesize that anti-TNFα
treatments modify the contribution of energy chains (aerobic, anaerobic and anaerobic
alactic) during the exercise.
Annual evaluation by Lipoxmax test and Wingate anaerobic test (WAnT) during 3 years or until
the transition from pediatric to adult care.
For healthy volunteer, only one lipaxmax and Wingate test.
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Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label
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