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Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial — ALLY  

Ischemic Stroke Clinical Trial

Official title:
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial

Clinical Trial Summary

Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS. Participants will receive IA TNK after achieving mTICI 2b or 2c reperfusion with standard of care MT. Patients enrolled into the study will be followed for 3 months after treatment with IA TNK.

Clinical Trial Description

As current MT technology is not amenable to retrieval of distal occlusions (M3/M4, etc), we hypothesize that IA lytic may play an important role as an adjunctive therapy to open up distal vessels (after the primary LVO has been removed) to achieve complete or near complete reperfusion. In this pilot trial, our goal is to assess the feasibility and safety of IA Tenecteplase (TNK) as an adjunctive therapy following standard of care mechanical thrombectomy (MT) in patients with AIS. A total of 20 patients will be enrolled into the ALLY pilot study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05172934
Study type Interventional
Source ProMedica Health System
Contact
Status Completed
Phase Phase 2
Start date March 15, 2022
Completion date November 1, 2023
View Details
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