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ED50 and ED95 of Remifentanil for Intubation Without NOL Variation — RemiTrach  

Intubation; Difficult or Failed Clinical Trial

Official title:
Determination of the ED50 and ED95 of Remifentanil to Perform Tracheal Intubation Without Significant NOL Index Variation

Clinical Trial Summary

Our aim, in this study, is to elucidate the optimal dosing range (ED50 and ED95) of bolus remifentanil in order to counter the painful stimuli resulting from direct laryngoscopy and tracheal intubation by using the NOL index. In order to maximize the clinical relevance of our findings, induction of general anesthesia will be done with standard medications and doses and laryngoscopy will be done with the Macintosh laryngoscope, the most common tool used for intubation in the operating room

Clinical Trial Description

Background: There are no study so far that determined the ED50 and ED95 of remifentanil to perform tracheal intubation by using the NOL index as the criterion measured to determine the failure (painful intubation) or the success (pain free intubation) of the assessed procedure. Objectives: To determine the ED50 and ED95 of remifentanil bolus to perform tracheal intubation without NOL index variating over threshold for nociceptive response (determined as a NOL index going over 20 - peak value of maximum 20) using the Macintosh blade when obtaining good conditions of intubation in anesthetized patients. Good conditions of intubation will be determined as obtaining a Cormack-Lehane grade I and II. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03744949
Study type Interventional
Source Ciusss de L'Est de l'Île de Montréal
Contact
Status Completed
Phase N/A
Start date March 14, 2018
Completion date September 30, 2021
View Details
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