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Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.

Insulin Resistance Clinical Trial

Official title:
Lipid and Carbohydrate Metabolism: Effects of Exercise

Clinical Trial Summary

The purpose of this study is to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.

Clinical Trial Description

In this study insulin resistant (IR), young offspring of parents with type 2 diabetes (18-46 years) and healthy, lean elderly individuals (65-90 years) will undergo 1H/13C MRS measurements of liver and muscle lipid and glycogen content before and after a high carbohydrate meal challenge. Hepatic de novo lipogenesis will be determined as the incorporation of deuterium, from deuterium labeled water (2H2O), into plasma triglycerides 5. These metabolic studies will be performed in 3 sets: Study Part 1: Resting, Study Part 2: After 1 bout of exercise and Study part 3: After 6 weeks of exercise training. Since intra-abdominal obesity has been postulated to be at the core of the metabolic derangements and directly responsible for the atherogenic dyslipidemia associated with the metabolic syndrome, the investigators will also measure intra-abdominal fat content by magnetic resonance imaging (MRI). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02196051
Study type Interventional
Source Yale University
Contact
Status Completed
Phase N/A
Start date January 1, 2017
Completion date June 29, 2020
View Details
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