Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Inflammation Clinical Trial

Official title: The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial

Status Recruiting

Clinical Trial Summary

Patients undergoing open colorectal surgery were randomly divided into two groups:

Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).

For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.

For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.

Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

Clinical Trial Description

Patients undergoing open colorectal surgery with tumor resection were randomised prospectively into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).

For the IV-Lido group (n=25), patients received a loading dose of 1.5 mg/kg of Lidocaine than a continuous infusion of 1.5 mg/kg/h over twenty-four hours.

For the IV-Keta goup(n=25), patients received a loading dose of 0.15mg/kg of Ketamine than a continuous injection of 0.15 mg/kg/h of Ketamine over twenty-four hours.

For both groups, plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively. Plasma IL-6 concentrations at each point were compared between the groups. ;

Related Conditions & MeSH terms

• Colorectal (Colon or Rectal) Cancer
• Inflammation

• NCT number: NCT06272461
• Study type: Interventional
• Source: University Tunis El Manar
• Contact: BEN ALI MECHAAL, Professor
• Phone: 72100533
• Email: mechaal_benali@yahoo.fr
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2023
• Completion date: June 30, 2024