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NCT05106075 Clinical Trial

Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages

Inflammation Clinical Trial

— RESOMACRO  

Official title:
Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05106075
Other study ID # 2020/562
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date July 7, 2021
Est. completion date January 7, 2024

Study information
Verified date October 2021
Source Centre Hospitalier Universitaire de Besancon
Contact Thomas CHERRIER, MCU-PH
Phone +33(0)768207057
Email tcherrier@unistra.fr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date January 7, 2024
Est. primary completion date January 7, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Age Limits (18-80 years) - Information and non-opposition for participating in the study - Patients suffering from periodontitis grade III ou IV - Patients suffering from microcristalline arthritis - patient with health insurance Exclusion Criteria: - patient under corticotherapy - pregnancy - non-compliant patient - patient with no health insurance - patient in exclusion period from an other study - legal incapacity

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• blood sample or joint fluid or gingival exudate
blood sample collected by peripheral blood mobilization joint fluid collected by punction gingival exudate collected with paper strips

Locations
Country Name City State
France CHRU Besançon Besançon
France Dentist'S Office Montbéliard

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Besancon

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Quantification of cytokine concentrations in samples by ELISA up to 2 months
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