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Inflammation clinical trials

View clinical trials related to Inflammation.

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NCT ID: NCT06054100 Completed - Clinical trials for Acute Coronary Syndrome

The Effect of Colchicine on Inflammation in ACS Patients

Start date: February 1, 2020
Phase: Phase 3
Study type: Interventional

This study will evaluate whether the anti-inflammatory effect of colchicine is beneficial in ACS patients

NCT ID: NCT06051487 Completed - Clinical trials for Gingival Inflammation

Evaluation of Anti Bacterial Effect of Titanium Dioxide Nanoparticles on Baseplates of Twin Block

Start date: March 11, 2022
Phase: N/A
Study type: Interventional

Background The objective of this study was to evaluate the antibacterial effect of Titanium dioxide nanoparticles incorporated into the acrylic baseplates of maxillary part of twin block appliances in orthodontic patients during the treatment period. Material and methods Twenty-six patients were selected randomly and divided into two groups(n=13). Test group patients were used orthodontic functional appliances containing Titanium dioxide nanoparticles in acrylic baseplates. Control group patients were used orthodontic functional appliances without Titanium dioxide nanoparticles in acrylic baseplates. Swap samples were taken from palatal gingiva facing fitting surface of acrylic component of maxillary part of twin block appliance for each patient at five times intervals (base line sample, after one, two, four, and six months) then cultured in blood agar plates to calculate bacterial colony count.

NCT ID: NCT06041425 Completed - Pain Clinical Trials

The Effects of Oxycodone Versus Sufentanil on Pain and Inflammatory Response After TACE

Start date: August 7, 2023
Phase: Phase 4
Study type: Interventional

The purpose of this randomized, double-blind trial was to compare the effects of preemptive Oxycodone and sufentanil at the same dose on pain and inflammatory response after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma. To study the effect of single dose intravenous injection of Oxycodone and sufentanil before TACE on inflammatory reaction after TACE; And (ii) evaluate the effects of different opioid drugs on pain and nausea/vomiting after TACE.

NCT ID: NCT06040931 Completed - Clinical trials for COPD Exacerbation Acute

Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPD

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases Chronic Obstructive Pulmonary Disease (COPD) is a heterogenous disease of the lungs that can comprise of different pathophysiological phenotypes, including emphysema, chronic bronchitis, and Small Airways Disease (SAD). COPD is also associated with chronic inflammation and this ongoing inflammation may result in airway remodeling and excessive mucus plugging within the small airways Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. The small airways have been defined as < 2mm diameter and arise from the 4th - 13th generation of airway branching (taking trachea as 1st generation to alveoli as 23rd), but on average arise by the 8th aim of this work is to study the relationship between neutrophilic airway inflammation, small airways dysfunction, and frequency of acute exacerbation in stable COPD patients

NCT ID: NCT06002750 Completed - Inflammation Clinical Trials

Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation

Start date: November 24, 2021
Phase:
Study type: Observational

The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are: - 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients; - 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.

NCT ID: NCT06002594 Completed - Clinical trials for Upper Respiratory Tract Infection

Examination of the Effectiveness of Nasal Irrigation Techniques in Infants With Nasal Congestion

Start date: August 15, 2019
Phase: N/A
Study type: Interventional

The research investigates the effects of high-volume and low-volume nasal irrigation techniques applied to relieve nasal congestion in infants with nasal congestion due to upper respiratory tract infections. The study examines the physiological parameters of infants who undergo nasal irrigation, crying duration, frequency of the procedure, and the baby's feeding patterns.

NCT ID: NCT05994391 Completed - Inflammation Clinical Trials

A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults

COG
Start date: June 3, 2022
Phase: N/A
Study type: Interventional

The potential impact of various dietary ingredients to improve cognitive function, mood, well-being, and overall levels of affects are largely undetermined. The purpose of this study is to determine the effects of a combination of two dietary supplements, Scutellaria baicalensis and Acacia catech, on cognitive function, well-being, mood, cognitive interferences, and inflammation.

NCT ID: NCT05985733 Completed - Inflammation Clinical Trials

Evaluation of Oxidative Stress and Inflammation Markers in Temporomandibular Disorders

Start date: June 19, 2020
Phase:
Study type: Observational

Background: The occurrence of many diseases has been associated with oxidative stress and disruption of antioxidant mechanisms. Temporomandibular Joint(TMJ) Disorders are also thought to develop with the onset of the destructive process in the tissues as a result of this balance being disrupted. Purpose: This study was designed to compare salivary and serum oxidative stress and inflammation markers of individuals with Temporomandibular Disorders (TMD) and healthy subjects. Study design, setting, and sample: A prospective cross-sectional study was conducted. 27 TMD patients diagnosed with disc displacement (DD) according to RDC/TMD and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum and saliva samples were taken from the patients and centrifuged, and stored at -80°C until analyzed. All samples were examined for IL-6, MDA and 8-OHdG concentrations. Predictor variable: Diagnosis of disc displacement (RDC/TMD) Main outcome variables: Levels of 8-OHdG, IL-6 and MDA Covariates: Age and gender

NCT ID: NCT05984641 Completed - Hemorrhoid Pain Clinical Trials

Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

Aim of the study is to assess the efficacy, safety and tolerability of CONAN® (Proctological Cream, Medical Device, Omikron Italia Srl) on most frequent symptoms in grade 1-2 of haemorrhoidal disease and anal fissures.

NCT ID: NCT05982665 Completed - Inflammation Clinical Trials

Effect of Inhaled Molecular Hydrogen on Recovery Process After Downhill Walking on the Treadmill

Start date: August 14, 2023
Phase: N/A
Study type: Interventional

This study assesses the effect of molecular hydrogen inhalation in healthy males on muscle soreness, fatigue, oxidative stress, and inflammation following eccentric muscle contraction during downhill walking on the treadmill.