Infertility, Female Clinical Trial
Official title:
Effects of Preimplantation Genetic Screening 2.0 on the Clinical Outcomes of Assisted Reproductive Treatment in Patients With Recurrent Pregnancy Loss : A Multi-center-based Prospective Randomized Clinical Trial
50%-60% of the known causes of recurrent pregnancy loss(RPL) are associated with embryonic
aneuploidy, such that preimplantation genetic screening (PGS) on embryos acquired by assisted
reproductive treatment should improve the rate of pregnancy and live birth in those patients.
In dispute though the clinical application of PGS has been, a series of studies show that the
new generation of PGS(PGS 2.0), based on blastocyst biopsy followed by whole genome analysis,
has significantly improved the clinical outcome of IVF treatment. At present, there is still
a need for the evidence of the use of PGS 2.0 in RPL patients, who may benefit from this
emerging technology considering the prevalence of genetic abnormalities and the number of
transferable embryos in this population.
An earlier single center RCT conducted by our IVF center displayed higher implantation rate,
clinical pregnancy rate and ongoing pregnancy rate calculated by per embryo transfer(ET)
cycle in IVF/ICSI+PGS group compared with IVF/ICSI group.
This multi-center prospective randomized clinical trial is to provide more data to determine
whether the clinical outcomes are significantly improved per treatment cycle such that
provide evidence for the application of PGS in RPL patients. Besides, risk factors of PGS
outcome are to be analyzed from multi-center data to build a model for prediction of the
possible outcomes of PGS and direction of the clinical choice.
n/a
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