Infertility Female Clinical Trial
Official title:
The Effect of Metformin on Fecundability in Obese Women Undergoing ART - the Correlation to Uterine Flow Parameters A Prospective Randomized Controlled Trial
The basis for obesity's impact on reproduction is not well characterised and there is a
controversy whether the key organ influenced by it are the ovaries or the uterus.
Insulin sensitizers ameliorate insulin resistance in obese patients. This study seeks to
determine if Metformin helps to increase fecundability by affecting the uterus in women
undergoing ART. As a surrogate marker- flows in the uterus will be tested during the
treatment.
Obesity has been long implicated in reduced reproductive potential and it has been shown to
impair conception and implantation. However, the basis for this adverse effect is still
obscure and there is a controversy whether the key organ influenced by it are the ovaries or
the uterus.
It is well established that insulin resistance is one of the main mechanisms of obesity's
negative influences on the reproductive organs in females. Insulin sensitizers ameliorate
insulin resistance in obese patients.
This study seeks to determine if Metformin ,an oral antidiabetic and insulin sensitizer,
helps to increase fecundability by affecting the uterus in women undergoing frozen-thawed
embryo transfer compared to the control group. As a surrogate marker- flows in the uterus
will be tested during the treatment.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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