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Infarction clinical trials

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NCT ID: NCT03829605 Not yet recruiting - Clinical trials for Myocardial Infarction

Plasma Hydrogen Sulfide, Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction

Start date: February 15, 2019
Phase:
Study type: Observational

Acute myocardial infarction (AMI) can cause heart failure, an irregular heartbeat, cardiogenic shock, or cardiac arrest. It is the major cause of morbidity and mortality in the general population. The diagnosis of AMI is complex basing on the clinical history, physical examination, cardiac markers, and a chest radiograph. Besides, considering that the mechanisms linking activation of inflammation and ACS are complex as well, progress in diagnosis and therapy improves little

NCT ID: NCT03826836 Not yet recruiting - Heart Failure Clinical Trials

Mind Our Heart Study

Start date: January 2019
Phase: N/A
Study type: Interventional

Patients with atherosclerotic cardiovascular disease (i.e. peripheral artery disease, ischemic heart failure, myocardial infarction) are randomised to (1) treatment as usual (i.e. best medical care) or (2) treatment as usual (i.e. best medical care) in combination with an eight-week mindfulness-based stress reduction programme.

NCT ID: NCT03786757 Not yet recruiting - Clinical trials for ST Segment Elevation Myocardial Infarction

Prevention of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant (EARLYmyo-LVT Ⅱ)

Start date: April 1, 2019
Phase: Phase 3
Study type: Interventional

Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events. This study aims to assess the efficacy and safety outcomes of Rivaroxaban on the prevention of post-STEMI left ventricular thrombus.

NCT ID: NCT03753269 Not yet recruiting - Clinical trials for ST Segment Elevation Myocardial Infarction

Early Intracoronary Administration of Fasudil in the Primary PCI of ST-segment-Elevation Myocardial Infarction

Start date: July 1, 2019
Phase: Phase 4
Study type: Interventional

The study aims to evaluate whether an early intracoronary administration of Fasudil Hydrochloride during primary PCI of STEMI can improve epicardial and myocardial perfusion as well as clinical outcomes.

NCT ID: NCT03735134 Not yet recruiting - Clinical trials for Myocardial Infarction

Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin

Start date: November 2018
Phase: N/A
Study type: Interventional

The aim of this research is to study the effect of a loading dose of colchicine on the occurrence of periprocedural myocardial infarction (PPMI) in elective percutaneous coronary intervention.

NCT ID: NCT03658031 Not yet recruiting - Clinical trials for Myocardial Infarction

Effect of Dapagliflozin on the Progression From Prediabetes to T2DM in Subjects With Myocardial Infarction

Start date: March 1, 2019
Phase: Phase 3
Study type: Interventional

It is hypothesize that, because dapagliflozin will reverse the metabolic defects responsible for the development of prediabetes (i.e. insulin resistance and beta cell dysfunction) and progression from prediabetes to T2DM (beta cell dysfunction) and will cause weight loss, it will markedly reduce the progression from prediabetes to T2DM and reverse glucose tolerance to NGT in patients with prediabetes experiencing acute myocardial infarction. Further, it is hypothesized that the hemodynamic actions of dapagliflzoin will exert cardiovascular benefit in subjects with prediabetes and acute MI by reducing cardiac remodeling, preserve LV function and decrease the risk of development of heart failure and hospitalization for heart failure. Hence, aim to examine the impact of SGLT2 inhibitor on T2DM and cardiovascular risk in patients with prediabetes and cardiovascular disease. The primary objective of the study is to examine the effect of dapagliflozin (10 mg) on the progression from prediabetes to T2DM in patients with prediabetes who experience acute myocardial infarction (MI). A secondary objective is to examine the effect of dapagliflozin on a composite of CV outcome including incidence and hospitalization for heart failure in patients with prediabetes with acute MI. Other secondary outcome is the change from baseline to end of study in LD systolic and diastolic function.

NCT ID: NCT03617159 Not yet recruiting - Clinical trials for Pediatric Cerebral Stroke

Role of Advanced Magnetic Resonance Imaging in Assessment of Pediatric Cerebral Stroke

Start date: October 2018
Phase:
Study type: Observational

Stroke can be ischemic, hemorrhagic, or both. Early recognition and treatment of pediatric stroke are critical in optimizing long-term functional outcomes, reducing morbidity and mortality, and preventing recurrent stroke. Neuroimaging plays a vital role in achieving this goal. Neuroimaging is usually the first step in diagnosis, helping discriminate between ischemic/hemorrhagic strokes and also in the identification of underlying potential causes. Multiparametric magnetic resonance imaging (MRI) plays a crucial role in assessing pediatric cerebral stroke including diffusion-weighted imaging (DWI), susceptibility weighted imaging (SWI) and magnetic resonance angiography (MRA).

NCT ID: NCT03613064 Not yet recruiting - Clinical trials for Coronary Artery Disease

Addressing Social Vulnerabilities in Cardiovascular Disease

Start date: January 2022
Phase: N/A
Study type: Interventional

The investigators will conduct a feasibility study of an enhanced transitional care intervention, that will: 1) automate identification and risk-stratification of patients with CHF and IHD with social vulnerabilities; 2) incorporate a new standardized social vulnerabilities screening tool into clinical care; 3) enable electronic referrals to community resources; and 4) add novel community-based interventions to the existing medically-oriented transitional care intervention that is the standard of care at the study hospital (Parkland Hospital in Dallas, Texas) and other hospitals nationwide.

NCT ID: NCT03533153 Not yet recruiting - Clinical trials for Myocardial Infarction

Intravenous MSC Therapy on Ischemia-Reperfusion Injury in Patients With Myocardial Infarction

Start date: March 1, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The investigators scheduled to assess the value of intravenous injection of WJ-MSC in patients with ST-segment elevation myocardial infarction (STEMI).

NCT ID: NCT03494751 Not yet recruiting - Clinical trials for Acute Myocardial Infarction

Heart Monitoring Device After Acute Myocardium Infarction

Monitor
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Verify the effectiveness of a Heart Monitor in preventing events in patients over 18 years after acute myocardial infarction in a clinical unit. Patients with neurological disease or congenital heart disease we excluded from the study.