Hyponatremia Clinical Trial
Official title:
Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy?
Mild hyponatremia is the commonest electrolyte imbalance in the older population. Recently,
association between hyponatremia and bone fractures in the ambulatory elderly has been
shown.
Mild chronic hyponatremia is causing falls and lead to hospitalisation because of attention
deficit.
Symptoms related to hyponatremia can be very subtle and difficult to detect clinically.
Twenty elderly patients, retirement homes residents, with serum sodium < 135mEq/L will be
included. They will be randomised. The physician will review the drug treatment of ten
patients in coordination with the opinion of pharmacologists. Drug treatment for ten other
patients wil remained unchanged during the three months of inclusion.
Useful elements of the medical records of patients randomized to the experimental arm will
be forwarded to the Pharmacovigilance Regional Center for opinion pharmacologist. The
notice, subject to the attention of physician of retirement homes, give rise to a
therapeutic approach towards the patient. It will be followed by weekly monitoring of serum
sodium for 4 weeks to evaluate the impact of the intervention. Thus, the effectiveness of
medical intervention will be evaluated by an objective biological criteria: serum sodium in
the fourth week. Secondary endpoints will evaluate the duration of normalization of serum
sodium and check the interest of correcting hyponatremia to improve postural capacities and
eventually reduce the number of falls in the medium term (three months).
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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