Effects of Recurrent PE on Women and Offspring

Hypertension Clinical Trial

— RPOH  

Official title:

The Effects of Recurrent PE on Women and Offspring's Health

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05134285
• Other study ID #: 81830045
• Status: Not yet recruiting
• Start date: January 2022
• Est. completion date: November 2024

Study information

• Verified date: November 2021
• Source: Guangzhou Medical University
• Contact: Dunjin Chen
• Phone: 18928916722
• Email: gzdrchen[@]gzhmu.edu.cn
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.

Description:

The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1000
• Est. completion date: November 2024
• Est. primary completion date: November 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 19 Years to 50 Years

Eligibility

Inclusion Criteria:

• women with at least twice of delivery history

Exclusion Criteria:

• women with chronic hypertension

Related Conditions & MeSH terms

• Hypertension
• Pre-Eclampsia
• Preeclampsia
• Recurrence

Intervention

Other:
• blood pressure,BMI, blood sample
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.

Locations

Country	Name	City	State
China	Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University	Guangzhou

Sponsors (1)

Lead Sponsor	Collaborator
Dunjin Chen

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	blood pressure and hypertension of women	blood pressure =140/90 mmHg	1year after the second deliver
Primary	blood pressure and hypertension of women	blood pressure =140/90 mmHg	3 years after the second deliver
Primary	blood pressure and hypertension of women	blood pressure =140/90 mmHg	5 years after the second deliver
Primary	blood pressure and hypertension of offspring	blood pressure=140/90 mmHg	1 year old
Primary	blood pressure and hypertension of offspring	blood pressure=140/90 mmHg	3 years old
Primary	blood pressure and hypertension of offspring	blood pressure=140/90 mmHg	5 years old
Primary	level of glycosylated hemoglobin in blood	women	1 year after the second deliver
Primary	level of glycosylated hemoglobin in blood	women	3 years after the second deliver
Primary	level of glycosylated hemoglobin in blood	women	5 years after the second deliver
Primary	level of cholesterol, LDL, HDL, VLDL-C in blood	women	1 year after the second deliver
Primary	level of cholesterol, LDL, HDL, VLDL-C in blood	women	3 years after the second deliver
Primary	level of cholesterol, LDL, HDL, VLDL-C in blood	women	5 years after the second deliver
Primary	level of FT3,FT4, and hTSH in blood	women	1year after the second deliver
Primary	level of FT3,FT4, and hTSH in blood	women	3 years after the second deliver
Primary	level of FT3,FT4, and hTSH in blood	women	5 years after the second deliver
Primary	level of AST and ALT in blood	women	1year after the second deliver
Primary	level of AST and ALT in blood	women	3 years after the second deliver
Primary	level of AST and ALT in blood	women	5 years after the second deliver
Secondary	BMI of offspring	weight(kg)/height(m)2	1 year old
Secondary	BMI of offspring	weight(kg)/height(m)2	3 years old
Secondary	BMI of offspring	weight(kg)/height(m)2	5 years old
Secondary	level of insulin in blood	women	1year after the second deliver
Secondary	level of insulin in blood	women	3 years after the second deliver
Secondary	level of insulin in blood	women	5 years after the second deliver
Secondary	level of fructosamine in blood	women	1year after the second deliver
Secondary	level of fructosamine in blood	women	3 years after the second deliver
Secondary	level of fructosamine in blood	women	5 years after the second deliver
Secondary	level of AI37??AI4??PRA?ALD?AngII in blood	women	1 year after the second deliver
Secondary	level of AI37??AI4??PRA?ALD?AngII in blood	women	3 years after the second deliver
Secondary	level of AI37??AI4??PRA?ALD?AngII in blood	women	5 years after the second deliver