Hypertension Clinical Trial
Official title:
Anti-Inflammatory and Endothelial Protectant Effects of Paricalcitol
The study is about possible protective effects of paricalcitol (Zemplar) upon inflammation, blood pressure and kidney function. Kidney Inflammation occurs when white blood cells become abnormally stimulated and accumulate in the kidney and cause damage to the kidney. The purpose of this study is to determine if paricalcitol helps improve kidney injury, blood pressure control and kidney function in patients with chronic kidney disease. The study will last about 7 weeks and involves about 8 visits to the medical center.
We hypothesize that use of paricalcitol in patients with chronic kidney disease will lead to
improvement in oxidative stress, inflammation, endothelial function and subsequently
ambulatory blood pressures and glomerular filtration rate. We will pursue our hypothesis by
the three specific aims:
Aim 1: To compare oxidative stress markers in patients treated with paricalcitol before and
after the study. Aim 2: To measure endothelial function by flow mediated dilation in
patients with chronic kidney disease before and after paricalcitol. Aim 3: To measure
actigraphy guided ambulatory blood pressure and GFR in the absence of changes in
anti-hypertensive medications in patients with chronic kidney disease.
The study will be double blind randomized pilot trial in 24 patients with chronic kidney
disease with 1:1:1 allocation to paricalcitol 1 microgram: paricalcitol 2 microgram:
Placebo.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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