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Clinical Trial Summary

Surgery-induced pain reveals its own metabolic and inflammatory responses, resulting in a further increase in noxious pathways that are already occurring. Even though it is difficult to distinguish whether the metabolic and inflammatory responses are pain-induced or surgical-induced, it is clear that pain can cause a response. This study aims to investigate the effects of erector spinae plane block on hyperglycemic response with enhanced recovery after cardiac surgery protocol.


Clinical Trial Description

The Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) program includes a perioperative multimodal, opioid-sparing pain management plan as an essential component of any comprehensive program. Included in a multimodal pain management plan are nonopioid systemic analgesic agents, regional and local anesthetic techniques, and judicious use of opioids. Considering that the most prominent form of stress response occurring during cardiac surgery is the severity of hyperglycemia, it is reasonable to examine the glucose values and the hematological parameters associated with stress response in the groups with and without block in order to understand the effect of the block. This study aims to examine blood glucose value and hematological parameters in patients who underwent cardiac surgery with ERAS, with and without preoperative bilateral erector spinae plane block (ESP). For this purpose, the presence of an obstacle in terms of ESP block application in the preoperative period will be investigated in patients who are prepared for cardiac surgery according to ERAS principles, and the patient's group will be determined accordingly. An analgesia protocol that does not include a regional technique will be applied to the patient in cases such as the patient's refusal to allow preoperative block and the presence of a situation that does not allow blockage in the block area. The perioperative characteristics of ERAS patients with and without ESP block will be examined, blood glucose will be closely monitored in the intraoperative period, and preop-postoperative hemogram-albumin-C reactive protein parameters will be recorded. ERAS patients with ESP block: After preparation in accordance with the ERAS protocol, ultrasound-guided bilateral ESP block will be performed with 20 ml of 0.025% bupivacaine at T5-7 levels in patients taken to the operating room in the preoperative period, and will be administered intraoperative low-dose remifentanil infusion and sevoflurane anesthesia. ERAS patients without ESP block: After preparation according to the ERAS protocol, patients will be administered lidocaine, ketamine, paracetamol, and intraoperative low-dose remifentanil infusion and sevoflurane anesthesia. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04924335
Study type Interventional
Source Ankara City Hospital Bilkent
Contact EDA BALCI, MD
Phone +90 533 629 77 60
Email [email protected]
Status Recruiting
Phase N/A
Start date March 1, 2021
Completion date August 1, 2021

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