Hypercholesterolemia Clinical Trial
Official title:
Can Cholesterol Lowering Drugs Influence Circulating Omega-3 Fatty Acid Levels
The objective of this study is to determine if the administration of a cholesterol lowering
drug like ezetimibe will reduce circulating omega-3 fatty acid (ALA) levels in patients with
heart disease and hypercholesterolemia.
The investigators hypothesize that their data will discover that patients receiving
ezetimibe require additional dietary supplementation with omega-3 supplements to insure that
these beneficial fatty acids are available to these patients.
All patients will undergo drug therapy as required to treat their clinical symptoms
including the use of other classes of cholesterol-lowering drugs like statins (that will not
interfere with intestinal cholesterol levels). One group of patients will be those who in
addition to there existing drug therapy are prescribed ezetimibe to lower circulating
cholesterol concentrations. A second group of patients will be those who are not prescribed
ezetimibe as part of their normal course of therapy. Blood samples will be taken from all
patients at the study baseline. All patients will be fasted for 12 hours prior to the blood
sample being taken. After 6 weeks a second blood sample will be taken. This will determine
if the drug intervention (ezetimibe) influenced the circulating omega-3 fatty acid
concentration.
It will also be of interest to determine if drug administration (ezetimibe) will influence
this process when higher levels of omega-3 fatty acids are given to the patients by dietary
supplements of ALA. Two additional groups of patients will consume a flaxseed oil supplement
containing 1g of ALA in the form of two capsules daily
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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