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HIV Switch Trial in Experienced Patients With Multiple Class Resistance Including NNRTI Resistance

HIV Infections Clinical Trial

Official title:
A Pilot, Prospective, Non-randomized Study to Evaluate the Safety and Efficacy of Switches From Etravirine to Doravirine, in Experienced Patients With Multiple Class Resistance Including NNRTI Resistance

Clinical Trial Summary

This is a pilot, open, prospective, non-randomized study to evaluate the safety and efficacy of switches from etravirine to doravirine, in experienced patients with multiple class resistance including NNRTI resistance. The other ARV medication (protease inhibitor, entry inhibitor and integrase inhibitor) that some patients receive, in addition to the NRTI and NNRTI, will not be changed. The study will be performed only on two sites

Clinical Trial Description

The duration of the study will be of 120 weeks: 24 for recruitment and 96 weeks of follow-up. The reasons for the study duration of 2 years is that, up to now, doravirine has not been studied in 2 or 3 classes multi-drug-resistance (MDR) and thus, demonstration of durability of effect over a prolonged period of time is as important as the short-term efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04334551
Study type Interventional
Source Clinique du Quartier Latin
Contact Ioannis vertzagias
Phone 5142853401
Email ivertzagias@cmql.ca
Status Recruiting
Phase Phase 4
Start date June 23, 2020
Completion date October 1, 2022
View Details
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