Hepatocellular Carcinoma Clinical Trial
Official title:
The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Compared With Transarterial Chemoembolization in Patients With Large and Unresectable Hepatocellular Carcinoma Staged BCLC A/B
The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) compared with transarterial chemoembolization (TACE) in patients with large and unresectable hepatocellular carcinoma staged BCLC A/B.
Transarterial chemoembolization (TACE) is the most widely used palliative treatment for
hepatocellular carcinoma (HCC) patients. While a number of studies demonstrate poor effect
of TACE for patients with large hepatocellular carcinoma staged BCLC A/B. Our previous
prospective study also revealed similar results of large HCC patients treated with TACE.
Recently, the results of our preliminary pilot study suggested that, compared with TACE,
hepatic arterial infusion chemotherapy (HAIC) may improve tumor response for HCC with large
HCC.
Thus, the investigators carried out this prospective nonrandomized control to demonstrate
the superiority of HAIC over TACE.
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