Hepatitis C Virus Clinical Trial
Official title:
Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans
This study will investigate the possible relationship between infection with hepatitis C
virus (HCV) and the development of certain hematologic cancers (Non-Hodgkin's lymphoma,
Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma) and thyroid cancer. HCV
causes chronic hepatitis, cirrhosis, and liver cancer. It is transmitted primarily through
injection drug use and transfusion of infected blood. Studies have shown that HCV may also be
linked to hematologic cancers and thyroid cancer.
This retrospective study will examine medical records from veterans with and without HCV
infection who previously received treatment in the Veterans Administration medical system.
Data collected on each subject will include the subject's race, sex, age and era of military
service, presence of liver disease or thyroiditis at their baseline clinic visit, number of
inpatient visits in the past 5 years and outpatient visits in the past year, and the presence
of various specified cancers. The prevalence of cancer and other conditions among
HCV-infected subjects and non-HCV infected subjects at baseline and the subsequent
development of the cancers of interest in these two groups will be compared and analyzed for
a possible causal relationship.
Hepatitis C virus (HCV) may be a cause of hematologic malignancies and thyroid cancer. HCV
infection is common among U.S. military veterans receiving care in the Veterans
Administration healthcare system. The investigators propose a retrospective cohort study
using VA administrative databases. A cohort of approximately 147,000 HCV-infected veterans
has been identified for the period 1997-2004. Likewise, a cohort of approximately 573,000
HCV-uninfected veterans has been identified for the same period. These subjects are being
evaluated for the diagnosis of hematologic malignancies, thyroid cancer, and related medical
conditions as recorded in VA databases. The comparison of the prevalence and incidence of
these cancers in the two cohorts will provide a test of the hypothesis that HCV infection can
cause these cancers.
The investigators will also evaluate the association between HCV infection and several other
medical conditions, which might be related to HCV infection, specifically: immune
thrombocytopenic purpura, autoimmune hemolytic anemia, cholangiocarcinoma, cholangitis, and
pancreatic cancer.
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