Heart Failure Clinical Trial
Official title:
Prevention of Hemorrhage After Implantation of Mechanical Circulatory Support
Main objective of the study is to demonstrate that a prophylactic treatment with VWF factor concentrate after implantation of continuous-flow left ventricular assist device (CF-LVAD) reduces the frequency of clinically significant bleeding within 3 months after implantation in comparison to the usual care. Adult patients with functional defects of VWF measured after implantation of continuous LVAD are randomly assigned to prophylactic treatment.
This time point was chosen because the bleeding events are maximal within the first 3 months
after implantation.
- Adult patients > 18 years who need a CF-LVAD due to advanced heart failure.
- Functional To determine the potential indication of Wilfactin® in the field of CF-LVAD
and avoid widespread use and to establish evidence-based recommendation To improve the
knowledge of the role of VWF concentrate in bleeding and angiogenesis after CF-LVAD
implantation and to provide some results about mechanism involved angiogenesis or
hemostasis.
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