Heart Disease Clinical Trial
Official title:
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research. Urocortins are proteins that appear to increase blood flow and heart pumping activity. There has been particular interest in the role of Urocortins 2 & 3 (subtypes of Urocortins) in heart failure. In this study, we will examine the effects and mechanisms of Urocortins 2 & 3 and the Corticotrophin Releasing Hormone Receptor Type 2 (CRH-R2) receptor (through which urocortins act) on forearm blood flow and release of natural blood clot dissolving factors in the forearm circulation of healthy volunteers. In this study, we will look at the role of the lining of the blood vessel (endothelium) in response to urocortin types 2 and 3. We hypothesise that urocortins 2 & 3 act via the endothelium to cause dilatation of the blood vessels and release of tissue-plasminogen activating factor (blood clot dissolving factor). We also hypothesise that urocortins have a role in maintaining the normal baseline level of blood flow in forearm arteries. In addition to the above, we will also look at the effect of temporarily blocking the effect of urocortins, using a specially designed blocker drug (Astressin 2B). Utilising the well-established technique of 'forearm venous occlusion plethysmography', we will be able to focus on the local effects of urocortins on arterial blood flow in forearm vessels, without affecting this system in the body as a whole.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03481322 -
Low Sodium Cooking Study
|
N/A | |
| Completed |
NCT00001638 -
Magnetic Resonance Imaging of the Blood Vessels of the Heart
|
||
| Completed |
NCT02376244 -
The Health Impact of High Intensity Exercise Training With Intervals During Cardiac Rehabilitation
|
N/A | |
| Completed |
NCT02523144 -
Dexmedetomidine in Children Having Transthoracic Echocardiography
|
Phase 4 | |
| Completed |
NCT02277379 -
Prediction of Bleeding and Transfusion Outcomes and Assessment of Perioperative Platelet Reactivity in Cardiac Surgery
|
N/A | |
| Completed |
NCT02045641 -
Pleural and Pericardial Effusion Following Open Heart Surgery
|
N/A | |
| Completed |
NCT01871090 -
Remote Device Interrogation In The Emergency Department
|
N/A | |
| Active, not recruiting |
NCT01400490 -
Eicosapentaenoic Acid (EPA)and Docosahexaenoic Acid Study
|
N/A | |
| Completed |
NCT01192360 -
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease
|
Phase 3 | |
| Terminated |
NCT00935766 -
Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
|
Phase 3 | |
| Completed |
NCT00745446 -
The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation
|
N/A | |
| Completed |
NCT00140816 -
Dairy Products and Metabolic Effects (Norwegian Part)
|
N/A | |
| Completed |
NCT00178620 -
Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization
|
Phase 4 | |
| Completed |
NCT00013949 -
Cardiovascular Vulnerability to Particulate Exposure
|
N/A | |
| Completed |
NCT01952171 -
The Genetic Basis of Congenital Heart Disease in Africa
|
||
| Recruiting |
NCT02933892 -
Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterization
|
Phase 4 | |
| Completed |
NCT02923518 -
Cardiac Screening of Middle Aged and Older Women and Men (Master Athletes)
|
||
| Withdrawn |
NCT02838355 -
Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients
|
N/A | |
| Terminated |
NCT02282163 -
Evaluation of Safety and Efficacy of Lumason in Pediatric Echocardiography
|
Phase 3 | |
| Active, not recruiting |
NCT02260466 -
Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.
|
N/A |