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Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects — DHTP  

Healthy Clinical Trial

Official title:
Single-blind, Randomized, Two-arm, Dose-response Study of DMT and Harmine in Healthy Subjects

Clinical Trial Summary

The goal of this clinical trial is to compare corresponding inter- and intraindividual pharmacokinetic and pharmacodynamic profiles including assessments of safety & tolerability.

Clinical Trial Description

Participants will undergo a series of six study days with varying doses of DMT and Harmine. The intervention is embedded in controlled environment and continuous psychological support. Pharmacokinetic and pharmacodynamic assessments are obtained over the course of 24 hours on each study visit to estimate dose-exposure relationship and drug-drug-interaction. Additionally, the occurrence of adverse events will be closely monitored throughout the whole study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05829603
Study type Interventional
Source Reconnect Labs
Contact
Status Completed
Phase Phase 1
Start date May 5, 2023
Completion date October 17, 2023
View Details
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