Effects of Breathing Patterns on Post-prandial Vascular Function

Healthy Clinical Trial

Official title:

The Effects of Different Breathing Styles on Post High-Fat Meal Blood Vessel Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04864184
• Other study ID #: 7374
• Status: Completed
• Phase: N/A
• Start date: December 1, 2020
• Est. completion date: September 30, 2021

Study information

• Verified date: November 2021
• Source: Texas State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: September 30, 2021
• Est. primary completion date: September 30, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Male participants ages 18-35 years

Exclusion Criteria:

• Infection within the previous 4 weeks

• Renal disorders

• Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias

• Chronic obstructive pulmonary disease

• Diabetes

• Inflammatory bowel disease

• HIV, rheumatoid arthritis, chronic or other inflammatory conditions

• Currently taking steroids or other anti-inflammatory medications

• Current use of nonsteroidal anti-inflammatory drugs

• Smoking

• Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher)

• Lactose intolerance

Related Conditions & MeSH terms

• Healthy
• Respiratory Aspiration

Intervention

Behavioral:
• Normal physiologic rate breathing
2-minute breathing exercises will be completed every 15 minutes.
• Slow breathing
2-minute breathing exercises will be completed every 15 minutes.

Locations

Country	Name	City	State
United States	Cardiovascular Physiology Laboratory-Texas State University	San Marcos	Texas

Sponsors (1)

Lead Sponsor	Collaborator
Texas State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in flow-mediated dilation	Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.	At baseline and at again 1, 2, 4 hours post high-fat meal consumption
Primary	Changes in oxidative stress	Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.	Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.