Healthy Clinical Trial
Official title:
Investigation of Fat and Carbohydrate Oxidation During Moderate Versus Vigorous Intensity Exercise in Healthy Volunteers With Sedentary Lifestyle
Exercise is widely suggested as an important lifestyle change for weight loss, however, the optimal level of intensity moderate versus vigorous remains unclear. It is known that in athletes, during very high-intensity exercise, fat oxidation is decreased and energy is gained mainly from carbohydrate utilization. The aim of this study is to find an optimal workload based on fat oxidation rate during exercise in volunteers with a sedentary lifestyle.
It is planned to recruit 12 healthy volunteers with a sedentary lifestyle in the study group.
Since different regimens (fed, fasted and moderate versus vigorous) will be compared in the
same subjects, no control group is necessary. Subjects will perform a cycling test with 5 min
incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load
will be selected after the incremental intensity exercise). The expiration of carbon dioxide
(CO2) and consumption of oxygen (O2) will be measured, to determine the total fatty acid and
carbohydrate oxidation during cycling. Concomitantly, it is planned to measure blood lactate
and glucose concentrations during exercise experiments as well as a wide range of blood
biochemistry parameters before and after exercise.
The investigators expect to find optimal conditions for the sedentary population for burning
of fat, which is the major source of energy during moderate-intensity exercise. Measurements
of the fat and carbohydrate oxidation in healthy volunteers with a sedentary lifestyle will
contribute to the understanding of exercise regimens for the most effective fat oxidation.
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