Healthy Clinical Trial
Official title:
The Comparison of Preconditioning Effect of Desflurane and Antiapoptotic Effect of Propofol in Patients With Kidney Transplantation
Ischemia/reperfusion (IR) injury is the major cause of early renal dysfunction and acute
renal failure of the transplanted kidney after renal transplantation. In 1986, Murry et al.
described the phenomenon "ischemic preconditioning". Also, it was reported that a few
non-ischemic stimuli could provide cellular tolerance against major ischemia through a
mechanism similar to ischemic preconditioning. In an animal study, 1 minimal alveolar
concentration of volatile anesthetics - a clinically relevant concentration - was reported
to have a protective effect against ischemia/reperfusion injury, the effect being variable
between types of anesthetics. Also, there were somm reports that intravenous anesthetics
such as propofol could reduce IR injury by decreasing oxidative stress and apoptosis.
By reducing the ischemia/reperfusion injury of the grafted kidney, the morbidity and
mortality related to renal transplantation can be reduced as well. The objective of this
study is to find out whether, according to the type of anesthetics (Desflurane vs.
Propofol), there is a difference in the protective effect against ischemia/reperfusion
injury of the grafted kidney in patients receiving renal transplantation.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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