Healthy Clinical Trial
Official title:
Determination of the Mean Values of Oxidative Stress Parameters in the Plasma of Healthy Subjects
Determination of the mean value of oxidative stress parameters in normals and of the plasma and serum levels, resp. of malondialdehyde, glutathion and superoxide dismutase in healthy subjects.
In certain situations, free radicals can be generated in an exaggerated manner and can
injure tissues and organs by interacting with lipids, proteins, or DNA. So, oxidative stress
has been implicated in a large number of human diseases. To survive, the human body has
developed a complex, efficient, and highly adaptive antioxidant defense system. The eye is
also protected against oxidative stress by several mechanisms involving antioxidant enzymes
such as catalase (CAT) and superoxide dismutase (SOD), as well as by low-molecular-weight
antioxidants such as glutathion (GSH) and ascorbate.
Primary open-angle glaucoma (POAG) is a chronic, slowly progressive optic neuropathy,
characterized by excavation of the optic nerve head (ONH) and a distinctive pattern of
visual field (VF) defects. The disease is multifactorial in origin, so that besides more
extensively investigated factors oxidative stress has also been proposed as a contributing
factor in the etiology of glaucomatous optic neuropathy. Oxidative stress represents a
harmful state defined by the presence of pathologic levels of reactive oxygen species (ROS)
relative to antioxidant defense.
Therefore, it would be also important to determine whether there is a relationship between
circulating levels of the defense parameters to oxidative stress like malondialdehyde, GSH
and SOD, and the occurrence of POAG.
Since there are only the limits of variation for these defense parameters available, mean
values of the plasma levels of malondialdehyde, glutathion and superoxide dismutase will be
determined in healthy subjects.
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