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NCT ID: NCT04735835 Recruiting - Healthy Clinical Trials

Personalized Responses to Dietary Composition Trial 3

Start date: July 20, 2020
Phase: N/A
Study type: Interventional

The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of testing postprandial responses to specific mixed meals, in addition to a free-living period with a dietary record for measuring responses to a large variety of meals consumed in a realistic context, where the role of external factors (e.g. exercise, sleep, time of day) on postprandial responses may be determined. For the first time this PREDICT study is built on top of a commercial product which will allow access to a much larger group of participants who are already collecting large amounts of data through digital and biochemical devices that can contribute to science.

NCT ID: NCT04734808 Recruiting - Healthy Clinical Trials

EEG Brain Activity At Various Cycling Intensities

Start date: February 1, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to investigate brain activity with EEG during incremental cycling at various cycling intensities.

NCT ID: NCT04718363 Recruiting - Healthy Clinical Trials

Effects of Foam Rolling Prior to PNF Stretching on Hamstring Flexibility and Thigh Skin Temperature in Healthy Subjects

PNF
Start date: January 27, 2021
Phase: N/A
Study type: Interventional

There is no study investigating the hamstring flexibility and skin temperature after combined warm-up techniques especially PNF and foam rolling. The main purpose of this study is to investigate the effects of foam roller application prior to proprioceptive neuromuscular facilitation stretching on hamstring flexibility and thigh skin temperature in healthy subjects.Secondly, it is aimed to compare the effects between non-vibration foam rolling and vibration foam rolling on measured parameters.

NCT ID: NCT04717466 Recruiting - Healthy Clinical Trials

Brain Changes in Psoriasis After Secukinumab Treatment

Start date: June 29, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the effect of a biologic drug targeting the Interleukin (IL)-17 pathway (secukinumab) on brain plasticity and examine whether the plastic changes correlate with the improvement of perception of well-being, itch, and pain in participants with psoriasis.

NCT ID: NCT04714294 Recruiting - Healthy Clinical Trials

Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers

Start date: September 8, 2020
Phase: Phase 1
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease characterized by persistent respiratory symptoms and incompletely reversible airflow limitation. It is usually caused by airway and / or alveolar abnormalities caused by obvious exposure to toxic particles or gases.COPD is currently the fourth leading cause of death in the world, and is expected to be the third leading cause of death by 2020.HPP737 as an oral PDE4 inhibitor for the treatment of COPD.Preclinical data showed that the activity of HPP737 was similar to that of rofloxacin, but HPP737 significantly reduced the permeability to CNS and may have better tolerance. HPP737 will be used to develop indications for chronic obstructive pulmonary disease, and PK study in Chinese people is going to to evaluate the safety and tolerability of HPP737 in healthy volunteers.

NCT ID: NCT04706481 Recruiting - Healthy Clinical Trials

Archival of Human Biological Samples in CU-Med Biobank

Start date: January 1, 2020
Phase:
Study type: Observational [Patient Registry]

CU-Med Biobank collaborates with different researchers for collecting and distributing human biospecimens and clinical data for assisting scientific research.

NCT ID: NCT04705532 Recruiting - Healthy Clinical Trials

Behavioral and Neurophysiological Effects of Multichannel Executive Network tDCS Combined With Preferred Music Stimulation

Start date: October 4, 2019
Phase: Phase 1
Study type: Interventional

This study aims at comparing the effects of transcranial direct current stimulation combined with music on neurophysiological outcomes in healthy participants. This study also aims to evaluate the effects of tDCS combined with music on cognition.

NCT ID: NCT04671797 Recruiting - Healthy Clinical Trials

Dinner Time 2: Effect of Delayed Eating or Sleeping on Metabolism

DT2
Start date: January 15, 2021
Phase: N/A
Study type: Interventional

This study examines the acute impact of eating an "early" versus "late" dinner. "Early" and "late" will be customized to individuals based on the individuals' own circadian rhythms. Healthy adults will have the adults' circadian rhythm assessed by measuring the adults' dim light melatonin onset (DLMO). Based on the timing of DLMO, participants will be randomized to eating dinner before DLMO or after DLMO. The investigators will also compare the effects of delaying sleep relative to dinner time. Participants will eat meals in the laboratory and have serial plasma samples collected to examine profiles of free fatty acids, glucose, insulin, triglycerides, and oxidation of dietary fat.

NCT ID: NCT04651036 Recruiting - Healthy Clinical Trials

A Phase 1 Study to Assess the Immunogenicity of QL0605 Compared to US Neulasta in Healthy Subjects

Start date: November 6, 2020
Phase: Phase 1
Study type: Interventional

The study was an assessor-blind, balanced, parallel, randomized, two-treatment, comparative immunogenicity study of multiple doses of subcutaneous (SC) Pegfilgrastim injection (6 mg/0.6 mL; Qilu Pharmaceutical Co., Ltd. proposed biosimilar QL0605 compared to innovator product, US-Neulasta) in healthy, adult, human subjects.

NCT ID: NCT04650048 Recruiting - Healthy Clinical Trials

Modulation of an Experimental Prolonged Pain Model Using High Definition Transcranial Direct Current Stimulation

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy subjects.