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Healthy Subjects clinical trials

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NCT ID: NCT05418582 Completed - Healthy Subjects Clinical Trials

Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine

Start date: January 25, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1, single-center, nonrandomized, open-label, 2-part, fixed-sequence, drug-drug interaction (DDI) study to assess the effect of multiple doses of itraconazole, a CYP3A4 enzyme inhibitor, on the single dose PK of DZD9008 in healthy adult subjects (Part A) and to assess the effect of multiple doses of carbamazepine, a CYP3A4 inducer, on the single dose PK of DZD9008 in healthy adult subjects (Part B).

NCT ID: NCT05403281 Completed - Healthy Subjects Clinical Trials

A Pharmacokinetic Study of DW6012 (FDC of Dapagliflozin and Sitagliptin) in Healthy Adult Volunteers

Start date: November 5, 2021
Phase: Phase 1
Study type: Interventional

This study is to compare and evaluate the safety and pharmacokinetic characteristics (PK) after administration of DW6012 and each component in healthy adult volunteers.

NCT ID: NCT05399030 Completed - Healthy Subjects Clinical Trials

A Phase I Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical Study of ICP-332 in Healthy Subjects

Start date: August 14, 2021
Phase: Phase 1
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, parallel group, single and multiple ascending dose phase I study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ICP-332 in Healthy Subjects

NCT ID: NCT05391880 Completed - Healthy Subjects Clinical Trials

Study of Orally Administered BEBT-503 in Healthy Subjects

Start date: August 26, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase I, randomized, double-blind, placebo-controlled, first-in-human study in which the safety, tolerability, and pharmacokinetic of orally administered BEBT-503 will be assessed in healthy adult subjects. The study will consist of 2 parts: a SAD phase (Part A) enrolling a total of 5 cohorts of healthy subjects; a MAD phase (Part B) enrolling 2 cohorts of healthy subjects; One cohort of Part A will receive BEBT-503 under both fasted and fed conditions to investigate the effect of food

NCT ID: NCT05381857 Completed - Healthy Subjects Clinical Trials

Genetic & Environmental Determinants Of Immune Phenotype Variance: A Longitudinal Assessment

MI-V3
Start date: March 15, 2022
Phase:
Study type: Observational

Effects of aging, genetics and environmental exposures on immune variation in a previously well-defined healthy population (NCT03905993).

NCT ID: NCT05371379 Not yet recruiting - Healthy Subjects Clinical Trials

Multiple Ascending Dose Study of CM338 in Healthy Volunteers

Start date: June 1, 2022
Phase: Phase 1
Study type: Interventional

This study was a multi-center, randomized, double blind, placebo-controlled, single-dose, dose escalation Phase I study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of CM338 with multiple dosing in healthy subjects.

NCT ID: NCT05355077 Withdrawn - Healthy Subjects Clinical Trials

Evaluate the Pharmacokinetics, Safety and Tolerability of JT001 Tablets

Start date: May 2, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1, open-label, dose-escalation, multiple-dose study to investigate pharmacokinetics and safety of JT001 (VV116) in Caucasian healthy subjects.

NCT ID: NCT05347758 Not yet recruiting - Healthy Subjects Clinical Trials

A Phase I Single- and Multiple- Ascending Dose and Food Effect Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7535 in Healthy Subjects

Start date: May 1, 2022
Phase: Phase 1
Study type: Interventional

This is a randomized, double-blinded, placebo-controlled study to evaluate the safety, tolerability, Pharmacokinetics and Pharmacodynamics of single ascending dose (Part A) and multiple ascending dose (Part B) of HRS-7535 in healthy subjects.

NCT ID: NCT05315622 Completed - Healthy Subjects Clinical Trials

Effects of the T12-L1 Vertebral Manipulation on Body Temperature, Arterial Tension and Cardiac Frequency

Start date: April 4, 2022
Phase: N/A
Study type: Interventional

Single-blinded Randomized Controlled Trial conducted amongst a sample of healthy subjects divided into two different groups: the experimental treatment will consist in bilateral T12-L1 vertebral manipulation, whereas the control group will receive a sham intervention consisting solely in applying tension without properly manipulating. Body temperature, arterial tension and cardiac frequency will be measured before and after the intervention. Changes in the aforementioned variables will be measured.

NCT ID: NCT05313152 Completed - Healthy Subjects Clinical Trials

Study of TAVO103A in Healthy Volunteers

Start date: April 5, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1, single ascending dose study designed to investigate TAVO103A, administered as an IV infusion up to 60 minutes in length to healthy adult subjects. This study is designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TAVO103A.