Gut Microbiota is Associated With Autoimmune Thyroid Disease

Gut Microbiota Clinical Trial

Official title: Gut Microbiota is Associated With Autoimmune Thyroid Disease(GD and HT)

Status Recruiting

Clinical Trial Summary

Autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Grave's disease (GD), are the most common organ-specific autoimmune diseases and affect more women than men, with a female-to-male ratio from 5 to 10. Many studies have indicated that alterations in the gut microbiota are important environmental factors in the development of inflammatory and autoimmune diseases. Investigators systematically performed a comparative analysis of the gut microbiota in AITD patients and healthy controls.

Clinical Trial Description

Autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Grave's disease (GD), are the most common organ-specific autoimmune diseases and affect more women than men, with a female-to-male ratio from 5 to 10. These two diseases are clinically diverse because in HT, T cells aid in the destruction of the thyroid epithelial cells (thyrocytes) and thyroid epithelial structure and eventual fibrous replacement of parenchymal tissue leading to hypothyroidism, whereas GD is primarily a humoral disease where auto-antibodies are generated against the thyroid stimulating hormone receptor (TSHR) leading to hyperthyroidism (2,163-165). However, these diseases still share several immunological features，and the disease may progress from one state to another as the autoimmune process evolves. Many studies have indicated that alterations in the gut microbiota are important environmental factors in the development of inflammatory and autoimmune diseases. Investigators systematically performed a comparative analysis of the gut microbiota in AITD patients and healthy controls. ;

Related Conditions & MeSH terms

• Gut Microbiota
• Thyroid Diseases

• NCT number: NCT03390582
• Study type: Observational
• Source: First Affiliated Hospital of Harbin Medical University
• Contact: Wei Yunwei
• Phone: +86-0451-85553099
• Email: hydwyw11@hotmail.com
• Status: Recruiting
• Phase: N/A
• Start date: April 20, 2017
• Completion date: November 1, 2021