Glioma — fMRI Study of Functional Reorganization in Glioma Patients
Citation(s)
Abd-El-Barr MM, Saleh E, Huang RY, Golby AJ Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med. 2013 Aug 1;5(4):333-346.
Desmurget M, Bonnetblanc F, Duffau H Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain. 2007 Apr;130(Pt 4):898-914. Epub 2006 Nov 21. Review.
Duffau H Diffuse low-grade gliomas and neuroplasticity. Diagn Interv Imaging. 2014 Oct;95(10):945-55. doi: 10.1016/j.diii.2014.08.001. Epub 2014 Sep 16. Review.
Duffau H Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol. 2005 Aug;4(8):476-86. Review.
Duffau H Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol. 2015 May;11(5):255-65. doi: 10.1038/nrneurol.2015.51. Epub 2015 Apr 7. Review.
Duffau H The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery. Cortex. 2014 Sep;58:325-37. doi: 10.1016/j.cortex.2013.08.005. Epub 2013 Aug 19. Review.
Marusyk A, Almendro V, Polyak K Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer. 2012 Apr 19;12(5):323-34. doi: 10.1038/nrc3261. Review.
Niu C, Zhang M, Min Z, Rana N, Zhang Q, Liu X, Li M, Lin P Motor network plasticity and low-frequency oscillations abnormalities in patients with brain gliomas: a functional MRI study. PLoS One. 2014 May 7;9(5):e96850. doi: 10.1371/journal.pone.0096850.
Tuntiyatorn L, Wuttiplakorn L, Laohawiriyakamol K Plasticity of the motor cortex in patients with brain tumors and arteriovenous malformations: a functional MR study. J Med Assoc Thai. 2011 Sep;94(9):1134-40.
Neuroimaging Study on the Recombination of Brain Motor and Language Function Induced by Glioma
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
