| Eligibility |
Inclusion Criteria:
1. At least 18 years of age at time of screening.
2. Ability to understand the purposes and risks of the study and has signed a written
informed consent document approved by the site-specific IRB.
3. Patient must present with biopsy and histology proven glioma following initial
treatment with 186RNL. The type and grade of glioma to follow the 2021 WHO
Classification of Tumors of the Central Nervous System, allowing Grade III and IV
gliomas.
4. At least 90 days from prior dose of 186RNL at time of screening.
5. Patients who receive treatment with antiepileptic medications must have a two-week
history of stable dose of antiepileptic without seizures prior to dosing.
6. Patients with corticosteroid requirements to control cerebral edema must be maintained
at a stable or decreasing dose for a minimum of two weeks without progression of
clinical symptoms.
7. A volume of enhancing tumor which falls within the treatment field volume being
evaluated in the respective cohort (see 4.1 Design).
8. ECOG performance status of 0 to 2; ECOG 3 acceptable if Principal Investigator and
treating physician confirm in patient's interest in study/re-treatment.
9. Life expectancy of at least 2 months
10. Acceptable liver function: Bilirubin = 1.5 times upper limit of normal and AST (SGOT)
and ALT (SGPT) = 3.0 times upper limit of normal (ULN)
11. Acceptable renal function: Serum creatinine =1.5xULN
12. Acceptable hematologic status (without hematologic support): ANC =1000 cells/uL,
Platelet count =100,000/uL if no bleeding, Hemoglobin =7.0 g/dL. Given the absence of
hematological toxicity in the ongoing recurrent glioblastoma trial (#12-02) and the
need for CED catheter placement, the Investigator and Sub-investigator (neurosurgeon)
placing the CED catheter may determine that it is in the patient's best interest and
acceptably safe to proceed with this criteria with hematological support or, if no
bleeding, Platelet count =75,000/uL without support, ANC 1000 cells/uL and Hemoglobin
=7.0 g/dL
13. All women of childbearing potential must have a negative serum pregnancy test at
screening. Male and female subjects must agree to use effective means of contraception
(for example, surgical sterilization or the use of barrier contraception with either a
condom or diaphragm in conjunction with spermicidal gel or an IUD) with their partner
from entry into the study through 6 months after the last dose.
14. Patients must have malignant glioma that has progressed on or after standard treatment
(surgery, radiotherapy, and/or chemotherapy) and are planned to undergo stereotactic
biopsy as per standard of care.
Exclusion Criteria:
1. The subject has evidence of acute intracranial or intratumoral hemorrhage either by
MRI or computerized tomography (CT) scan. Subjects with resolving hemorrhage changes,
punctate hemorrhage, or hemosiderin are eligible.
2. The subject has contraindications to CNS Magnetic Resonance Imaging (MRI).
3. The subject has not recovered to National Cancer Institute (NCI) Common Terminology
Criteria for any prior Adverse Events (CTCAE) v4.0 Grade = 1 from AEs (except
alopecia, anemia and lymphopenia) due to antineoplastic agents, investigational drugs,
or other medications that were administered prior to study.
4. The subject is pregnant or breast-feeding.
5. The subject has serious intercurrent illness, as determined by the treating physician,
which would compromise either patient safety include:
1. Uncontrolled hypertension (two or more blood pressure readings performed at
screening of > 150 mmHg systolic or > 100 mmHg diastolic) despite optimal
treatment
2. non-healing wound, ulcer, or bone fracture
3. clinically significant cardiac arrhythmias affecting cardiac function
4. untreated hypothyroidism
5. uncontrolled systemic infection
6. symptomatic congestive heart failure or unstable, untreated angina pectoris
within 3 months prior study drug
7. myocardial infarction, stroke, transient ischemic attack within 6 months
8. known active malignancy (other than glioma) except non-melanoma skin cancer or
carcinoma in-situ in the cervix
6. The subject has an inherited bleeding diathesis or coagulopathy with the risk of
bleeding.
7. The subject has received any of the following prior anticancer therapy:
1. Non-standard radiation therapy such as brachytherapy, systemic radioisotope
therapy, or intra-operative radiotherapy (IORT) to the target site.
2. Other CNS radiation therapy within 12 weeks of screening.
3. Systemic therapy (including investigational agents and small-molecule kinase
inhibitors) or non-cytotoxic hormonal therapy (e.g., tamoxifen) within 14 days or
5 half-lives, whichever is shorter, prior first dose of study drug
4. Biologic agents (antibodies, immune modulators, vaccines, cytokines) within 21
days prior to first dose of study drug
5. Nitrosoureas or mitomycin C within 42 days, or metronomic/protracted low-dose
chemotherapy within 14 days, or other cytotoxic chemotherapy within 28 days,
prior to first dose of study drug
6. Prior CNS treatment with carmustine wafers
7. Patients who are currently receiving any other investigational agents and/or who
have received an investigational agent in the prior 28 days from screening.
8. Patient actively enrolled in an ongoing investigational drug or device trial
excluding follow-up only in a previously trial.
8. Multifocal progression or involvement of the leptomeninges.
9. Psychiatric illness/social situations that would limit compliance with the study
requirements.
10. Infratentorial disease unless Investigator and neurosurgeon agree it is treated
disease.
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