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Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma

Glioblastoma Clinical Trial

Official title:
Phase II Clinical Trial of Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma

Clinical Trial Summary

This research study is studying a combination of drugs with radiation as a possible treatment for Glioblastoma. The drugs involved in this study are: - Bavituximab - Temozolomide

Clinical Trial Description

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied. The FDA (the U.S. Food and Drug Administration) has not approved Bavituximab as a treatment for any disease. The FDA has approved Temozolomide as a treatment option for this disease. In this research study, the investigators are studying how the combination of Bavituximab, Temozolomide, and radiation affects this cancer. The current standard care of treatment for newly diagnosed glioblastoma is the combination of Temozolomide and radiation. Temozolomide causes cell death and radiation shrinks and kills the cancer cells. Bavituximab may activate (cause) the immune system to attack the cancer cells as well as target tumor cells themselves to kill them. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03139916
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Completed
Phase Phase 2
Start date September 13, 2017
Completion date August 31, 2022
View Details
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