Gingivitis Clinical Trial
Official title:
Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial
The number of orthodontic treatment provided to Brazilian population has been increased.
Unfortunately, some negative effects such as gum bleeding and bad breath are commonly
observed. It partially happens because tooth brushing and flossing become more difficult in
the presence of braces. Therefore, there is a need for clinical protocols able to maintain
the mouth healthy during orthodontic treatment.
Considering that proper use of mouthwashes by in individuals without braces is accompanied
by decrease in plaque and gum inflammation levels, it was hypothesized that, during
orthodontic treatment their anti-gingivitis and anti-plaque properties would positively
affect oral health. Objectives: The present study will compare the effects of two
commercially available mouthwashes with a placebo mouthwash in orthodontic patients wearing
fixed appliances.
Whole-mouth clinical examinations will be performed in periodontally healthy patients 15
days before, at the day of bonding and also 3 and 6 months after braces bonding. Hard and
soft tissues status, presence of gingivitis and amount of dental plaque will be monitored to
determine mouthwashes efficacy. At these same time-points plaque samples will be collected
from dental sites and braces surfaces aiming at determining total levels of bacteria and
levels of specific bacteria related to gum disease. After a full-mouth ultrasonic
debridement to remove dental plaque, stains and tartar, patients will be randomly assigned
to an Essential oils, Cetylpyridinium chloride or a placebo mouthwash for 6 months (40
ml/day). Further, samples of orthodontic wires will be analyzed under microscopy to check
whether regular use of mouthwashes increases the risk of corrosion or not.
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