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Gingivitis clinical trials

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NCT ID: NCT03142607 Recruiting - Gingivitis Clinical Trials

Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis

Start date: February 3, 2017
Phase: Phase 3
Study type: Interventional

Patient presenting to the dental clinic with gingivitis and fulfilling the inclusion criteria will be included in the study after taking informed consent. Participants will be divided into three groups. Each group will be instructed to apply metronidazole gel, chlorhexidine gel or combination of metronidazole and chlorhexidine gel on the marginal gingiva. Measurement for the gingival index will be taken at baseline, at 2 weeks and at 4 weeks interval

NCT ID: NCT03087240 Recruiting - Clinical trials for Rheumatoid Arthritis

Dental Prophylaxis and Rheumatoid Arthritis

PREPARA II
Start date: February 28, 2017
Phase: N/A
Study type: Interventional

This study evaluates the influence of dental prophylaxis on disease activity of Rheumatoid Arthritis. In addition to standard antirheumatic therapy, recently the question has been raised whether or not there is a supplementary beneficial effect due to professional teeth cleaning. So far just a few studies pursued this question, indicating that prophylaxis by dental professionals can alleviate the symptoms of Rheumatoid Arthritis. To further evaluate this question, in our study half of the participants will receive dental prophylaxis at their first visit, after 2 weeks and 3 months, while the other half will receive professional teeth cleaning after 3 months only.

NCT ID: NCT02809313 Recruiting - Gingivitis Clinical Trials

Clinical and Microbiological Effects of Lactobacillus Rhamnosus in Treatment of Gingivitis

Start date: March 2016
Phase: Phase 2
Study type: Interventional

The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic sachet as an adjunct to scaling and root planning (SRP). Material and methods: Thirty six gingivitis patients will be recruited and monitored clinically and microbiologically at baseline and 3-6 months after therapy. All patients will receive scaling and periodontal treatment and randomly will be assigned over an experimental (SRP + probiotic, n=18) or control (SRP + placebo, n=18) group. The sachet will be used once per day during 3 months.

NCT ID: NCT02801773 Recruiting - Gingivitis Clinical Trials

Clinical Effect of Lactobacillus Reuteri in Treatment of Gingivitis

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The aim of this randomized placebo- controlled clinical trials is to evaluate the effects of Lactobacillus reuteri containing probiotic lozenges as an adjunct to scaling and root planning (SRP). Material and methods: Thirty six gingivitis patients will be recruited and monitored clinically at baseline, 3 and 6 month after therapy. All patients will receive scaling and periodontal treatment and randomly will be assigned over an experimental (SRP + probiotic, N=18) or control (SRP+ placebo, n=18) group. The lozenges will be used once per day during 3 month.

NCT ID: NCT02684682 Recruiting - Gingivitis Clinical Trials

Frequency of Self-performed Mechanical Control of Plaque

Start date: February 2016
Phase: N/A
Study type: Interventional

The purpose of this blind randomized clinical trial is to evaluate different frequencies in self-mechanical control of plaque in individuals with historic of periodontitis and in periodic and preventive maintenance in order to assess which frequencies are compatible with maintaining gingival health.

NCT ID: NCT02267239 Recruiting - Periodontitis Clinical Trials

Methodology Antiseptic Application, Influence on Oral Biofilm.

Start date: October 2014
Phase: Phase 4
Study type: Interventional

The study has the objective to compare two different methodology of application the antiseptic on the oral biofilm will be formed during 48h in situ on a specific device. The first one using the immersion in the antiseptic solution, as much of the authors did in the past. And the second way doing a active mouthwash, as the manufacturer recommends. The study will compare two different antiseptic solutions, the chlorhexidine (0.2% Oraldine Perio) and the essential oils (Listerine Mentol) with the two different application and compared the bacterial vitality, thickness and covering grade between solutions and with a basal sample.

NCT ID: NCT01782170 Recruiting - Gingivitis Clinical Trials

Efficacy of Iocide Oral Rinse Against Gingival Inflammation

Start date: February 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to explore the efficacy of Iocide oral rinse in a human clinical trial of gingivitis. Iocide oral rinse will be evaluated against a placebo rinse. Indices for gingivitis, plaque and bleeding will be scored and blood tests will be performed to determine the effect of the antimicrobial oral rinse on relative levels of biological markers of inflammation.

NCT ID: NCT01778699 Recruiting - Dental Caries Clinical Trials

Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2).

Start date: February 2013
Phase: Phase 4
Study type: Interventional

In a previous study the efficacy of Lb CD2 on interim covariates related to caries development was tested. So, it was decided to plan a new study on schoolchildren from the same area. The aim of the present research protocol was to evaluate the anticariogenic effect of probiotics daily used, on the caries development in children. The null hypothesis was that the probiotic Lb CD2 would not modify the caries risk of the children. Moreover, the study will be carried out to investigate the plaque acidogenicity in situ following the regular consumption of a probiotic product compared to a control group. Objective: To determine the effect of a regularly consumed probiotic on the development of new caries lesions. Study design: Double blind, placebo-controlled, longitudinal study, monocentric, national, in situ