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Gingivitis clinical trials

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NCT ID: NCT06048627 Recruiting - Gingivitis Clinical Trials

Anti-gingivitis Mouthrinse

Start date: March 6, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to prove whether a fluoride/zinc lactate containing mouthrinse is able to reduce dental plaque and gingival inflammation in patients who have gingivitis when applied twice daily during brushing at home over a period of 12 weeks.

NCT ID: NCT06029283 Recruiting - Clinical trials for Cardiovascular Diseases

Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health

Start date: April 15, 2024
Phase: N/A
Study type: Interventional

The purpose of this research is to determine the effects of a chewing gum containing dietary nitrate to gingival and heart health. Dietary nitrates are commonly found in leafy vegetables and beets. The information learned from the study may help further understand the interconnection of oral health and heart health. The study is looking for individuals who present with mild to moderate gum irritation or bleeding. In the study participants will be randomized into either a group that will use a chewing gum containing dietary nitrate, or use a placebo chewing gum during a three-week period. Participants in the study will have a simple gingival exam, x-rays if needed, and small samples of saliva and blood collected. All participants will also undergo a routine tooth cleaning. Participants will be asked to breathe in a tube to sample the levels of nitric oxide. Finally, participants will have their heart health measured with a device that is like a blood pressure cuff.

NCT ID: NCT06006429 Recruiting - Periodontitis Clinical Trials

Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools

Odonto3D
Start date: May 11, 2022
Phase: N/A
Study type: Interventional

Periodontal diseases and dental pathologies are highly prevalent oral diseases. Thirty-three to fifty percent of adult population presented at least one untreated caries and more than 50% of French population are affected by severe periodontitis. These diseases affect dental organ or periodontal attached system but could have negative impact on general health, quality of life, word and individual well-being. Association between chronic diseases as diabetes, rheumatoid arthritis, cardiovascular diseases, and oral health have been well investigated. Dental and periodontal diagnosis is dependent of various clinical parameters time consuming and dependent operator. It represents a public health challenge. Informatic analysis detecting diseases could be a time gain and a more precise diagnosis tool. Today, any software or algorithm allow automatized detection, clinical qualitative or quantitative indices recording while these informations are present in numeric models

NCT ID: NCT05989750 Recruiting - White Spot Lesion Clinical Trials

Air-polishing With Erythritol During Orthodontic Tretament

AirPort
Start date: September 11, 2023
Phase: N/A
Study type: Interventional

Patients with multi-bracketed fixed orthodontic treatment are at increased risk of developing white spot lesions (WSL) and gingivitis. Various preventive strategies have been examined to prevent the development of WSLs. During initial non-surgical periodontal therapy, the use of subgingival air-polishing with erythritol powder has shown promising results in reducing deep pockets and gingival inflammation. The efficacy of its use as monotherapy in preventing WSLs and gingival inflammation in patients during orthodontic treatment, has not yet been tested. The primary objective of the present study is to compare the effectiveness of an air-polishing device used as monotherapy versus ultrasonic instrumentation (the current gold standard procedure) in preventing white spot lesions (WSL) and gingivitis among young patients undergoing multi-bracketed fixed orthodontic treatment.

NCT ID: NCT05968742 Recruiting - Gingivitis Clinical Trials

Variation in Gingival Inflammatory Responses

Start date: June 30, 2023
Phase: N/A
Study type: Interventional

The aim of this NIH National Institute of Dental and Craniofacial Research (NIDCR) funded study is to identify molecular mechanisms underlying observed variations in human responses to natural accumulation and maturation of dental plaque.

NCT ID: NCT05835453 Recruiting - Gingivitis Clinical Trials

At-home Bleaching Using Clear Aligners

Start date: April 14, 2023
Phase: N/A
Study type: Interventional

The aim of the present project is to clinically evaluate the bleaching effectiveness, tooth sensitivity, gingival irritation and patient´s satisfaction during a at-home bleaching with 10% carbamide peroxide using a conventional bleaching tray or a clear aligner.

NCT ID: NCT05825742 Recruiting - Clinical trials for Orthodontic Appliance Complication

Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment

Start date: September 5, 2023
Phase: N/A
Study type: Interventional

This study is designed to determine the efficacy of the Lumoral method on oral health in adolescents undergoing fixed orthodontic treatment. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long term. In addition, the device might have a photobiomodulation effect on periodontal tissues.

NCT ID: NCT05816512 Recruiting - Periodontitis Clinical Trials

Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children

GNPG
Start date: April 1, 2023
Phase: N/A
Study type: Interventional

The study is randomized controlled trial ... The null hypothesis of the present study is that there is no antibacterial efficacy of gold nanoparticles of pelargonium graveolens mouthwash against Streptococcus mutans and Candida Albicans . Meanwhile the alternative hypothesis of the present study is that gold nanoparticles of pelargonium graveolens mouthwash have antimicrobial activity against Streptococcus mutans and Candida Albicans .

NCT ID: NCT05813236 Recruiting - Clinical trials for Periodontal Diseases

NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery

NOQMOQS
Start date: June 28, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to prove that Novosyn Quick and Monosyn Quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery. In order to show equivalence between Novosyn Quick and Monosyn Quick EHS, which is composed of 3 parameters: clinical signs of reepithelization, clinical signs of haemostasis and clinical signs of inflammation, will be calculated for each suture 10 ± 5 days postoperatively and cannot differ more than 2 points. Furthermore, complications, the handling of the suture material, pain, satisfaction of the patient and bacterial contamination of the thread (optional) will also be assessed as secondary objectives.

NCT ID: NCT05786820 Recruiting - Periodontitis Clinical Trials

Impact of Pycnogenol® on Gingival Inflammation

PINEGIN
Start date: March 17, 2022
Phase: N/A
Study type: Interventional

This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract (Pycnogenol®) on clinical signs of gingival inflammation in a cohort of periodontal aftercare patients