Gastric Cancer Clinical Trial
Official title:
Efficacy and Safety of Perioperative Chemotherapy Plus PD-1 Antibody (Camrelizumabin) the Locally Advanced Adenocarcinoma of Stomach or Gastroesophageal Junction
For locally advanced gastric cance, neoadjuvant chemotherapy can increase the resectability
of tumor, and finally improve the long-term survival.
Combination of perioperative PD-1 antibody and chemotherapy for locally advanced gastric
cancer could be a novel therapy to increase response rate and resectability and reduce
recurrence rate. Camrelizumab（SHR-1210） in this study is a Chinese anti-PD-1 monoclonal
antibody for injection which has been approved for melanoma and Hepatocellular carcinoma.
This study is a single center, open-label, randomized comparative phase II clinical trial to
evaluate safety and efficacy of Camrelizumab in combination with perioperative chemotherapy
in locally advanced adenocarcinoma of stomach or gastroesophageal junction. Differences in T
cell expression were detected by single cell RNA sequencing to screen people who were more
sensitive to immunotherapy.
Gastric cancer is one of the most common malignancies in China with incidence and mortality
both ranking the 2nd among malignancies in China. Surgery is the only possible way to cure
gastric cancer, however, over 80-90% of gastric cancer patients in China are in advanced
stage. Locally advanced gastric cancer could be cured by multi-disciplinary therapies
including surgery, chemotherapy and radiotherapy. Neoadjuvant chemotherapy can increase the
resectability of tumor, and finally improve the long-term survival. However, the therapeutic
effects remain unsatisfactory.
Combination of perioperative PD-1 antibody and chemotherapy for locally advanced gastric
cancer could be a novel therapy to increase response rate and resectability and reduce
recurrence rate. Camrelizumab in this study is a Chinese anti-PD-1 monoclonal antibody for
injection which has been approved for melanoma and Hepatocellular carcinoma .This study is a
single center, open-label, randomized comparative phase II clinical trial to evaluate safety
and efficacy of Camrelizumab in combination with perioperative chemotherapy in locally
advanced adenocarcinoma of stomach or gastroesophageal junction. Differences in T cell
expression were detected by single cell RNA sequencing to screen people who were more
sensitive to immunotherapy.
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