Gastric Cancer Clinical Trial
Official title:
Phase I/II, Multicenter, Single-Arm Clinical Trial of Panitumumab in Combination With Cisplatin, Fluourouracil and Docetaxel (DCF) in Locally Advanced or Metastatic Cancer of the Stomach and Gastro-oesophageal Junction.
Investigators propose to study the effect of panitumumab when combined with an active regimen, such as DCF (Docetaxel/Cisplatin/Fluourouracil), in previously untreated patients with advanced cancer of the stomach.
Investigators propose a phase I/II study in order to evaluate the effect of panitumumab when
combined with an active regimen, such as DCF (Docetaxel/Cisplatin/Fluourouracil), in
chemotherapy - naive patients with advanced cancer of the stomach.
Investigators hypothesize that the addition of panitumumab to DCF regimen in advanced cancer
of the stomach and gastroesophageal junction is feasible, well tolerated and could achieve
an objective response rate of greater than 40%.
The 2-weekly schedule of DCF will be used as chemotherapy since a recently presented trial
demonstrated a comparable efficacy but a more favourable toxicity profile comparable to the
3-weekly schedule.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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