Fear Clinical Trial - Impact of Estrogen on Fear Extinction R61

Status Completed

Clinical Trial Summary

The goal of this project is to examine how estrogen may influence the resting-state connectivity and the extinction-induced activation of the fear extinction network.

Clinical Trial Description

The aim of the study was to examine the influence of exogenous estrogen administration on the activation of the fear extinction network in women. Functional MRI data and psychophysiological indices were collected to test the influence of estrogen on women's ability to regulate conditioned fear responses. Women underwent a 3 day experimental paradigm using classical fear conditioning. The first day was conducted outside the scanner, while days 2 and 3 were done inside the fMRI scanner and tested fear extinction learning and recall in days 2 and 3, respectively. The estrogen (or placebo) pill was given just hours before extinction learning test on day 2. No followups were conducted after women completed the 3 day study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02673606
Study type	Interventional
Source	NYU Langone Health
Contact
Status	Completed
Phase	Phase 1
Start date	January 2013
Completion date	April 15, 2019

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