Fatigue Clinical Trial
Official title:
Remote Ischaemic Conditioning for Fatigue After Stroke (RICFAST) - a Pilot, Double-blind, Randomised, Placebo Controlled Trial
This is a pilot randomised control trial to assess the safety, compliance, and acceptability of delivering a 6-week programme of remote ischaemic conditioning (RIC) to stroke patients suffering with fatigue, and study feasibility. A minimum of 34 patients who have suffered an ischeamic or haemorrhagic stroke and who suffer from fatigue, will be recruited and randomised to receive a 6-week programme of either RIC or a sham intervention.
Up to 75% of stroke patients suffer from fatigue, the effect of which can be physical,
cognitive or emotional, and presents a large barrier to progressing rehabilitation.
Remote ischaemic conditioning (RIC) is a procedure whereby ischaemia is induced to a limb for
short periods of time by inflating pressure cuffs around arms or legs to above systolic
pressures (mmHg). This procedure is performed for periods that avoid physical injury to the
limbs, but induce neurohormonal, systemic or vascular changes in the body. Such changes often
result in improved collateralisation of blood supply to various areas of the body, as well as
improved efficiencies of cellular metabolism. This may enhance the physical abilities of
patients undergoing rehabilitation after stroke, particularly when aiming to improve
endurance and fatigue.
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