Galactose Mediated Glycogen Resynthesis

Exercise Clinical Trial

Official title:

Galactose Mediated Glycogen Resynthesis and the Effects on Metabolism During Subsequent Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03903861
• Other study ID #: ERN_19-0308
• Status: Completed
• Phase: N/A
• Start date: July 1, 2019
• Est. completion date: May 1, 2020

Study information

• Verified date: December 2022
• Source: University of Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

Description:

Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.

Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: May 1, 2020
• Est. primary completion date: May 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:.

• Body mass index in the range: 18.5 - 27.5 kg/m2

• Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week

• Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)

Exclusion Criteria:

• Lidocaine allergy

• Current participation in another scientific/clinical study

• Bleeding disorder/s

• Current or recent smoker to include vaping (last 60 days)

• Vegan

• Existence of food intolerances

• Poor recent health as indicated in the general health questionnaire

• Engage in uncommon eating practices (e.g. sustained periods of fasting)

• Diagnosed with galactosemia

Related Conditions & MeSH terms

• Exercise

Intervention

Other:
• Glucose alone
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.
• Galactose alone
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.
• Glucose and galactose
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

Locations

Country	Name	City	State
United Kingdom	School of Sport, Exercise and Rehabilitation Sciences	Birmingham	West Midlands

Sponsors (2)

Lead Sponsor	Collaborator
University of Birmingham	Dairy Management Inc.

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle glycogen synthesis rates (mmol/kg/dm/h)	Muscle glycogen synthesis rates over the post-exercise recovery period	4 hours
Secondary	Carbohydrate oxidation rates (g/min)	Total, exogenous and endogenous carbohydrate oxidation during a secondary bout of exercise	Up to 90 minutes
Secondary	Fat oxidation rates (g/min)	Fat oxidation during a secondary bout of exercise	Up to 90 minutes
Secondary	Plasma glucose (mmol/L)	Plasma glucose during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Serum insulin (mU/L)	Serum insulin during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Plasma galactose (mmol/L)	Plasma galactose during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Plasma lactate (mmol/L)	Plasma lactate during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Plasma non-esterified fatty acids (mmol/L)	Plasma non-esterified fatty acids during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Plasma glycerol (umol/L)	Plasma glycerol during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Secondary	Plasma glucagon (pmol/L)	Plasma glucagon during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours